Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem.
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …

Organophosphorus agents (OP s) irreversibly inhibit acetylcholinesterase (AC hE) causing a
major cholinergic syndrome. The medical counter‐measures of OP poisoning have not …

Toxicity of organophosphorus compounds (OPs) remains a major public health concern due
to their widespread use as pesticides and the existence of nerve agents. Their common …

This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Sažetak Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents
(NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter …

Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027,
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …

Background Based on in vitro and in vivo rat experiments, the newly developed
acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the …

At the present, only four antidotes are in use in therapy for poisoning by organophosphorus
compounds: 2-PAM, HI-6, obidoxime and trimedoxime. Numerous compounds have been …

Organophosphates (OP) inhibit acetylcholinesterase (AChE, EC 3.1. 1.7), both in peripheral
tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due …

Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-
positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes …