Despite being the hallmark of cancer that is responsible for the highest number of deaths,
very little is known about the biology of metastasis. Metastatic disease typically manifests …

The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …

Tumour recurrence is a serious impediment to cancer treatment, but the mechanisms
involved are poorly understood. The most frequently used anti-tumour therapies …

Disseminated tumor cells (DTCs) are known to enter a state of dormancy that is achieved via
growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major …

In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after
years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to …

Extracellular vesicles (EVs) have emerged as important players of cancer initiation and
progression through cell-cell communication. They have been recognized as critical …