Small angle X-ray diffraction as a tool for structural characterization of muscle disease
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …
structural information from striated muscle fibers under hydrated physiological conditions …
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force
Contraction in striated muscle is initiated by calcium binding to troponin complexes, but it is
now understood that dynamic transition of myosin between resting, ordered OFF states on …
now understood that dynamic transition of myosin between resting, ordered OFF states on …
Titin force in muscle cells alters lattice order, thick and thin filament protein formation
Skeletal muscle force production is increased at longer compared to shorter muscle lengths
because of length-dependent priming of thick filament proteins in the contractile unit before …
because of length-dependent priming of thick filament proteins in the contractile unit before …
The super-relaxed state and length dependent activation in porcine myocardium
Rationale: Myofilament length-dependent activation (LDA) is the key underlying mechanism
of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the …
of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the …
Cardiac myosin filaments are directly regulated by calcium
Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions
W Ma, CL Del Rio, L Qi, M Prodanovic… - Proceedings of the …, 2024 - National Acad Sciences
Mavacamten is a FDA-approved small-molecule therapeutic designed to regulate cardiac
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …
In situ time-resolved X-ray scattering study of isotactic polypropylene in additive manufacturing
Using a specially designed apparatus, which collects simultaneous temperature and X-ray
scattering data, we performed in situ measurements of the filament during MatEx 3D printing …
scattering data, we performed in situ measurements of the filament during MatEx 3D printing …
Myosin head configurations in resting and contracting murine skeletal muscle
Transgenic mouse models have been important tools for studying the relationship of
genotype to phenotype for human diseases, including those of skeletal muscle. We show …
genotype to phenotype for human diseases, including those of skeletal muscle. We show …
EMD-57033 augments the contractility in porcine myocardium by promoting the activation of myosin in thick filaments
Sufficient cardiac contractility is necessary to ensure the sufficient cardiac output to provide
an adequate end-organ perfusion. Inadequate cardiac output and the diminished perfusion …
an adequate end-organ perfusion. Inadequate cardiac output and the diminished perfusion …
The structural OFF and ON states of myosin can be decoupled from the biochemical super-and disordered-relaxed states
There is a growing awareness that both thick-filament and classical thin-filament regulations
play central roles in modulating muscle contraction. Myosin ATPase assays have …
play central roles in modulating muscle contraction. Myosin ATPase assays have …