Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …

Treatments that block tumour necrosis factor (TNF) have major beneficial effects in several
autoimmune and rheumatic diseases, including rheumatoid arthritis. However, some …

Regulatory T (Treg) cells maintain immune homeostasis by inhibiting abnormal/overactive
immune responses to both autogenic and nonautogenic antigens. Treg cells play an …

The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most
cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly …

Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

TNFR2+ regulatory T cells preferentially accumulate in the tumor microenvironment, express
high levels of immunosuppressive molecules and possess strong suppressive activity. Our …

Hepatocellular carcinoma (HCC) is one of the most lethal tumors in China and worldwide,
although first-line therapies for HCC, such as atezolizumab and bevacizumab, have been …