Implantable drug delivery systems and foreign body reaction: Traversing the current clinical landscape

A Fayzullin, A Bakulina, K Mikaelyan, A Shekhter… - Bioengineering, 2021 - mdpi.com
Precise delivery of therapeutics to the target structures is essential for treatment efficiency
and safety. Drug administration via conventional routes requires overcoming multiple …

[HTML][HTML] Pharmacological approaches for the prevention of breast implant capsular contracture

E Guimier, L Carson, B David, JM Lambert… - journal of surgical …, 2022 - Elsevier
Capsular contracture is a common complication associated with breast implants following
reconstructive or aesthetic surgery in which a tight or constricting scar tissue capsule forms …

[HTML][HTML] SMI-Capsular Fibrosis and Biofilm Dynamics: Molecular Mechanisms, Clinical Implications, and Antimicrobial Approaches

I Schoberleitner, M Lackner, DC Coraça-Huber… - International Journal of …, 2024 - mdpi.com
Silicone mammary implants (SMIs) frequently result in capsular fibrosis, which is marked by
the overproduction of fibrous tissue surrounding the implant. This review provides a detailed …

Semipermeable barrier-assisted electrophoretic deposition of robust collagen membranes

A Antoshin, O Dubinin, L Miao, E Istranova… - Journal of Materials …, 2023 - Springer
Collagen membranes with high robustness and a defined stable biodegradation are of a
great interest for dental surgery. Electrophoretic deposition (EPD) is a perspective candidate …

Biomaterials and extracellular vesicle delivery: current status, applications and challenges

KS Leung, S Shirazi, LF Cooper, S Ravindran - Cells, 2022 - mdpi.com
In this review, we will discuss the current status of extracellular vesicle (EV) delivery via
biopolymeric scaffolds for therapeutic applications and the challenges associated with the …

Implants as targeted drug delivery systems

EO Bakhrushina, NB Demina - Pharmaceutical Chemistry Journal, 2022 - Springer
This review considers implants as modern drug delivery systems. Methods of their
production by hot melt extrusion, direct pressing, and 3D printing are described. The …

An electrospun macrodevice for durable encapsulation of human cells with consistent secretion of therapeutic antibodies

S Imaichi-Kobayashi, R Kassab, A Piersigilli… - Biomaterials, 2023 - Elsevier
Frequent subcutaneous or intravenous administrations of therapeutic biomolecules can be
costly and inconvenient for patients. Implantation of encapsulated recombinant cells …

Passivated Hydrogel Interface: Armor Against Foreign Body Response and Inflammation in Small-Diameter Vascular Grafts

M Zhou, Z Wang, M Li, Q Chen, S Zhang, J Wang - Biomaterials, 2024 - Elsevier
The development of small-diameter vascular grafts (SDVG) still faces significant challenges,
particularly in overcoming blockages within vessels. A key issue is the foreign-body …

Surface topography of PLA implants defines the outcome of foreign body reaction: An in vivo study

E Ivanova, A Fayzullin, N Minaev, I Dolganova… - Polymers, 2023 - mdpi.com
The formation of a dense fibrous capsule around the foreign body and its contracture is the
most common complication of biomaterial implantation. The aim of our research is to find out …

A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation

A Fayzullin, G Vladimirov, A Kuryanova… - Stem Cell Research & …, 2022 - Springer
One of the severe complications occurring because of the patient's intubation is tracheal
stenosis. Its incidence has significantly risen because of the COVID-19 pandemic and tends …