The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil)
reduce the risks of macular degeneration and cancers, but the mechanisms by which these …

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …

Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …

Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …

Persistent activation of signal transducers and activator of transcription 3 (STAT3) has been
closely related to growth, survival, proliferation, metastasis, and angiogenesis of various …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

Abstract Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth
endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main …

To identify regulators of triple-negative breast cancer (TNBC), gene expression profiles of
malignant parts of TNBC (mTNBC) and normal adjacent (nadj) parts of the same breasts …