The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Tooth defects are an extremely common health condition that affects millions of individuals.
Currently used dental repair treatments include fillings for caries, endodontic treatment for …

Evolutionary biology is paying increasing attention to the mechanisms that enable
phenotypic plasticity, evolvability, and extra‐genetic inheritance. Yet, there is a concern that …

Abstract Development of tooth shape is regulated by the enamel knot signalling centre, at
least in mammals. Fgf signalling regulates differential proliferation between the enamel knot …

Development has often been viewed as a constraining force on morphological adaptation,
but its precise influence, especially on evolutionary rates, is poorly understood. Placental …

During embryonic development, organs undergo distinct and programmed morphological
changes as they develop into their functional forms. While genetics and biochemical signals …

Developmental complexity stemming from the dynamic interplay between genetic and
biomechanic factors canalizes the ways genotypes and phenotypes can change in …

Background Mammalian premolars and molars (cheek teeth) are teeth with multiple cusps,
which are important characteristics of mammals. Endothermic mammals have high basal …

Tooth development is governed largely by epithelial–mesenchymal interactions and is
mediated by numerous signaling pathways. This type of morphogenetic processes has been …

Renewal of integumentary organs occurs cyclically throughout an organism's lifetime, but
the mechanism that initiates each cycle remains largely unknown. In a miniature pig model …