Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel
expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby …

Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …

BACKGROUND: The roles of infiltrating macrophages within the tumor microenvironment
are complex because of their functional variety. The aim of this study is to examine the role …

The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood
vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and …

There is controversy over the histogenesis of Kaposi's sarcoma (KS) from lymphatic or blood
vessel endothelium. D2-40 is a novel monoclonal antibody to an Mr 40,000 O-linked …

Carcinoma in situ testis (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a
pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male …

Lymphatic invasion is a commonly reported histopathological finding in the assessment of
primary tumors. In some studies, it has been found to be a predictor of shorter disease-free …

Peptide-based epitope tagging technology is universally used in nearly all kind of research
projects that involve biochemical characterization of a target protein, but not many systems …

Abstract Podoplanin (PDPN/Aggrus/T1α), a platelet aggregation-inducing mucin-like
sialoglycoprotein, is highly expressed in many cancers and normal tissues. A neutralizing …

BACKGROUND. Podoplanin is a mucin‐like glycoprotein that is important in
lymphangiogenesis but not blood vessel formation. Recent studies suggested a potential …