Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …

Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient
deployment of mitochondrial tasks, organelle homeostasis needs to be preserved …

As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated
levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic …

Despite the emergence of mitochondria as key regulators of innate immunity, the
mechanisms underlying the generation and release of immunostimulatory alarmins by …

Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

It is well-known that mitochondrial DNA (mtDNA) can escape to intracellular or extracellular
compartments under different stress conditions, yet understanding their escape mechanisms …

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights
a potential causal role in dementia | eLife Skip to Content eLife logo eLife home page Menu …

Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two global epidemics that
share several metabolic defects, such as insulin resistance, impaired glucose metabolism …

Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria due to their higher bioenergetic demand. Mitochondrial dysfunction is closely …