Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with
bleak outcome. According to National Cancer Institute's SEER database, the average five …

In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer, and assessing
its histopathological grade requires visual inspection by an experienced pathologist. In this …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world.
Alpha-fetoprotein (AFP) is considered as a diagnostic and prognostic tumorous marker for …

Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …

Liver cancer is the fourth leading cause of cancer related mortality in the world, with
hepatocellular carcinoma (HCC) representing the most common primary subtype. Two …

The telomerase reverse transcriptase is upregulated in the majority of human cancers and
contributes directly to cell transformation. Here we report that hTERT is phosphorylated at …

Cancer proteomics has become a powerful technique for characterizing the protein markers
driving transformation of malignancy, tracing proteome variation triggered by therapeutics …

The Ser/Thr protein kinase MELK (maternal embryonic leucine zipper kinase) has been
considered an attractive therapeutic target for managing cancer since 2005. Studies using …

Background Abnormal expression of protein kinase membrane associated
tyrosine/threonine 1 (PKMYT1) is closely associated with multiple types of cancers. In the …