Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …

Tissue-resident macrophages display varying phenotypic and functional properties that are
largely specified by their local environment. One of these functions, phagocytosis, mediates …

Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical
application stems from our understanding of the inhibitory effect of the corticosteroid …

Epithelial restitution is an essential process that is required to repair barrier function at
mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in …

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to
changes in intracellular Ca2+ levels. A unique class of these proteins—annexins—can bind …

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

Understanding the circuits that promote an efficient resolution of inflammation is crucial to
deciphering the molecular and cellular processes required to promote tissue repair …

Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the
maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years …