Current advances on nanomaterials interfering with lactate metabolism for tumor therapy
Q Cheng, XL Shi, QL Li, L Wang, Z Wang - Advanced Science, 2024 - Wiley Online Library
Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …
Small molecule inhibitors for cancer metabolism: promising prospects to be explored
D Liu, HP Wang, XX Li, JF Liu, YL Zhang… - Journal of Cancer …, 2023 - Springer
Background Abnormal metabolism is the main hallmark of cancer, and cancer metabolism
plays an important role in tumorigenesis, metastasis, and drug resistance. Therefore …
plays an important role in tumorigenesis, metastasis, and drug resistance. Therefore …
Terconazole, an azole antifungal drug, increases cytotoxicity in antimitotic drug-treated resistant cancer cells with substrate-specific P-gp inhibitory activity
JS Lee, Y Oh, JH Park, SY Kyung, HS Kim… - International Journal of …, 2022 - mdpi.com
Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …
Nutritional deficiency induces nucleus pulposus cell apoptosis via the ATF4-PKM2-AKT signal axis
N Zhou, B Shen, C Bai, L Ma, S Wang, D Wu - BMC Musculoskeletal …, 2022 - Springer
Background The intervertebral disc is the largest avascular tissue in the human body. The
nucleus pulposus (NP) consumes glucose and oxygen to generate energy to maintain …
nucleus pulposus (NP) consumes glucose and oxygen to generate energy to maintain …
Combination treatment using pyruvate kinase M2 inhibitors for the sensitization of high density triple-negative breast cancer cells
JS Lee, Y Oh, JS Lee, JH Park, JK Shin, JH Han… - in vivo, 2022 - iv.iiarjournals.org
Abstract Background/Aim: Few studies have examined the correlation between pyruvate
kinase M2 (PKM2) overexpression and triple-negative breast cancer (TNBC). TNBC is …
kinase M2 (PKM2) overexpression and triple-negative breast cancer (TNBC). TNBC is …
Compound 3K attenuates isoproterenol-induced cardiac hypertrophy by inhibiting pyruvate kinase M2 (PKM2) pathway
M Rihan, SS Sharma - Life Sciences, 2024 - Elsevier
Aim Chronic sympathetic stimulation has been identified as a primary factor in the
pathogenesis of cardiac hypertrophy (CH). However, there is no appropriate treatment …
pathogenesis of cardiac hypertrophy (CH). However, there is no appropriate treatment …
The USP10/13 inhibitor, spautin-1, attenuates the progression of glioblastoma by independently regulating RAF-ERK mediated glycolysis and SKP2.
SV Kona, SV Kalivendi - Biochimica et Biophysica Acta (BBA)-Molecular …, 2024 - Elsevier
Glioblastoma is a malignant brain tumor with poor prognosis. Though several dysregulated
pathways were found to mediate the tumor progression, hyperactivation of RAS-RAF-ERK …
pathways were found to mediate the tumor progression, hyperactivation of RAS-RAF-ERK …
[HTML][HTML] Low-Dose Perifosine, a Phase II Phospholipid Akt Inhibitor, Selectively Sensitizes Drug-Resistant ABCB1-Overexpressing Cancer Cells
JH Park, H Lee, T Zheng, JK Shin… - Biomolecules & …, 2024 - pmc.ncbi.nlm.nih.gov
We identified drugs or mechanisms targeting ABCB1 (or P-glycoprotein; P-gp)-
overexpressing drug-resistant cancer populations, given that these cells play a key role in …
overexpressing drug-resistant cancer populations, given that these cells play a key role in …
Low-dose pimecrolimus, an FDA-approved calcineurin inhibitor, sensitizes drug-resistant cancer cells via strong P-gp inhibition
JH Park, JS Lee, JK Shin, S Sharma, HS Kim… - Anticancer …, 2023 - ar.iiarjournals.org
Background/Aim: Co-treatment with calcineurin inhibitors, such as tacrolimus and
cyclosporin A, can sensitize chemotherapy-resistant cancer cells with P-glycoprotein (P-gp) …
cyclosporin A, can sensitize chemotherapy-resistant cancer cells with P-glycoprotein (P-gp) …
Co-treatment With Aripiprazole and Vincristine Sensitizes P-Glycoprotein-Overexpressing Drug-resistant MCF-7/ADR Breast Cancer Cells
JK Shin, HS Kim, S Yoon - Anticancer Research, 2024 - ar.iiarjournals.org
Background/Aim: Evidence supports that use of aripiprazole sensitizes drug-resistant oral
cancer cells. The aim of the study was to investigate whether aripiprazole can achieve …
cancer cells. The aim of the study was to investigate whether aripiprazole can achieve …