Abstract Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal
features from epithelial cells, occur during some biological processes and are classified into …

Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

The complex cross‐talk of intricate intercellular signaling networks between the tumor and
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …

Hypoxia, a condition of low oxygen tension in tissues, has emerged as a crucial factor in
tumor pathophysiology. Hypoxic microenvironment gives rise to altered cellular metabolism …

The conversion of cells with an epithelial phenotype into cells with a mesenchymal
phenotype, referred to as epithelial–mesenchymal transition, is a critical process for …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

A common feature of many solid tumors is low oxygen conditions due to inadequate blood
supply. Hypoxia induces hypoxia inducible factor (HIF) stabilization and downstream …

Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …