Rapid advances in genomics have opened unprecedented possibilities to explore the
mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia …

A generic level of chromatin organization generated by the interplay between cohesin and
CTCF suffices to limit promiscuous interactions between regulatory elements, but a lineage …

Topologically associating domain (TAD) boundaries are the flanking edges of TADs, also
known as insulated neighborhoods, within the 3D structure of genomes. A prominent feature …

Expression of Protocadherin (Pcdh) genes is critical to the generation of neuron identity and
wiring of the nervous system. Pcdhα genes are arranged in clusters and exhibit a range of …

In developing B cells, V (D) J recombination assembles exons encoding IgH and Igκ
variable regions from hundreds of gene segments clustered across Igh and Igk loci. V, D and …

The dynamic folding of genomes regulates numerous biological processes, including
antigen receptor (AgR) gene assembly. We show that, unlike other AgR loci, homotypic …

The expressed Ab repertoire is a critical determinant of immune-related phenotypes. Ab-
encoding transcripts are distinct from other expressed genes because they are transcribed …

Purpose Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the
world. Oncofetal proteins are the optimal diagnostic biomarkers and therapeutic targets for …

While extended loop extrusion across the entire Igh locus controls VH‐DJH recombination,
local regulatory sequences, such as the PAIR elements, may also activate VH gene …

Lymphocyte development culminates with generation of mature B and T cells that express
unique antigen receptors on the cell surface. Genes that encode the two chains of B or T cell …