Biochemical and genetic characterization of D-type cyclins, their cyclin D–dependent
kinases (CDK4 and CDK6), and the polypeptide CDK4/6 inhibitor p16INK4 over two …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

The widely accepted model of G1 cell cycle progression proposes that cyclin D: Cdk4/6
inactivates the Rb tumor suppressor during early G1 phase by progressive multi …

The function and activity of a protein are often modulated by other proteins with which it
interacts. This review is intended as a practical guide to the analysis of such protein-protein …

Cells prepare for S phase during the G1 phase of the cell cycle. Cell biological methods
have provided knowledge of cycle kinetics and of substages of G1 that are determined by …

The retinoblastoma gene is mutated in several types of human cancer and is the best
characterized of the tumour-suppressor genes. A mouse strain has been constructed in …

The retinoblastoma gene was identified over a decade ago as the first tumor suppressor.
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …

For the past decade, cellular oncogenes have attracted the attention of biologists intent on
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …

Although it is generally believed that the product of the retinoblastoma susceptibility gene
(RB7) is an important regulator of cell proliferation, the biochemical mechanism for its action …

A family of vertebrate cdc2-related kinases has been identified, and these kinases are
candidates for roles in cell cycle regulation. Here, we show that the human PLSTIRE gene …