Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Abstract α-Synuclein, a key pathological component of Parkinson's disease, has been
implicated in the activation of the innate and adaptive immune system. This immune …

Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

Background Parkinson's disease (PD) affects an estimated 7 to 10 million people worldwide,
and only symptomatic treatments are presently available to relieve the consequences of …

Background Converging evidence suggests a role for microglia-mediated
neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a …

Background: Parkinson's disease (PD) is characterized by loss of dopaminergic neurons
and intraneuronal accumulation of alpha-synuclein, both in the basal ganglia and in …

Parkinson's disease (PD) is a neurodegenerative disorder etiologically linked to the loss of
substantia nigra (SN) dopaminergic neurons in the mid-brain. The etiopathology of sporadic …

Parkinson's disease (PD) is marked by a loss of dopamine neurons, decreased dopamine
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …

Objective To assess the presence of brain and systemic inflammation in subjects newly
diagnosed with Parkinson's disease (PD). Background Evidence for a pathophysiologic role …