The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized.
The historical record is explored from both biochemical and theoretical perspectives …

Homology modeling plays a central role in determining protein structure in the structural
genomics project. The importance of homology modeling has been steadily increasing …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

As large-scale re-sequencing of genomes reveals many protein mutations, especially in
human cancer tissues, prediction of their likely functional impact becomes important …

Motivation: All residues in a protein are not equally important. Some are essential for the
proper structure and function of the protein, whereas others can be readily replaced …

The ability to separate correct models of protein structures from less correct models is of the
greatest importance for protein structure prediction methods. Several studies have examined …

The importance of a residue for maintaining the structure and function of a protein can
usually be inferred from how conserved it appears in a multiple sequence alignment of that …

Motivation: Amino acid sequence alignments are widely used in the analysis of protein
structure, function and evolutionary relationships. Proteins within a superfamily usually …

Heat shock proteins (HSPs) are a type of functionally related proteins present in all living
organisms, both prokaryotes and eukaryotes. They play essential roles in protein–protein …

The RNA recognition motif (RRM) is the most common RNA-binding domain in eukaryotes.
Differences in RRM sequences dictate, in part, both RNA and protein-binding specificities …