Background Fluorescence-guided surgery (FGS) is a technique used to enhance
visualization of tumor margins in order to increase the extent of tumor resection in glioma …

Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of
high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5 …

We demonstrate for the first time the application of an endoscopic fluorescence lifetime
imaging microscopy (FLIM) system to the intraoperative diagnosis of glioblastoma …

Significance: Although the clinical potential for Raman spectroscopy (RS) has been
anticipated for decades, it has only recently been used in neurosurgery. Still, few devices …

Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering,
biophysics, computer science, medicine, biology, and chemistry, helping us understand light …

The study of biological systems in their real environmental conditions is crucial to decipher
the true image of structures and processes underlying their functionality. In this regard …

Biomarkers are indicators of biological processes and hold promise for the diagnosis and
treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked …

Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

Background Fluorescence lifetime imaging (FLIM) is a novel imaging technique that
generates image contrast between different states of tissue due to differences in …

We suggest using the wide-field imaging Mueller polarimetry to contrast optically anisotropic
fiber tracts of healthy brain white matter for the detection of brain tumor borders during …