Inflammatory pathways in alcoholic steatohepatitis

B Gao, MF Ahmad, LE Nagy, H Tsukamoto - Journal of hepatology, 2019 - Elsevier
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

[HTML][HTML] The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD

Z Cheng, L Yang, H Chu - Journal of Advanced Research, 2024 - Elsevier
Background The liver disorders caused by alcohol abuse are termed alcoholic-related liver
disease (ALD), including alcoholic steatosis, alcoholic steatohepatitis alcoholic hepatitis …

Cholangiocyte-derived exosomal lncRNA H19 promotes macrophage activation and hepatic inflammation under cholestatic conditions

X Li, R Liu, Y Wang, W Zhu, D Zhao, X Wang, H Yang… - Cells, 2020 - mdpi.com
Activation of hepatic macrophages represents the critical driving force to promote cholestatic
liver injury. Exosomes, as important small extracellular vesicles released by almost all types …

Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4

F Sun, Y Sun, J Zhu, X Wang, C Ji, J Zhang… - Stem cell research & …, 2022 - Springer
Background As a leading cause of vision decline and severe blindness in adults, diabetic
retinopathy (DR) is characterized by the aggravation of retinal oxidative stress and apoptosis …

Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in cells of distant organ

S Sur, M Khatun, R Steele, TS Isbell, R Ray… - International Journal of …, 2021 - mdpi.com
SARS-CoV-2 infection can cause cytokine storm and may overshoot immunity in humans;
however, it remains to be determined whether virus-induced soluble mediators from infected …

Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice

JH Hwang, YS Park, HS Kim, D Kim, SH Lee… - Journal of Controlled …, 2023 - Elsevier
Plants-releasing exosome-like nanovesicles (PENs) contain miRNA, bioactive lipids,
mRNAs, and proteins to exert antioxidant, anti-inflammatory, and regenerative activity …

From endogenous compounds as biomarkers to plasma‐derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics‐absorption …

D Rodrigues, A Rowland - Clinical Pharmacology & …, 2019 - Wiley Online Library
It is now established that a drug's pharmacokinetics (PK) absorption, distribution,
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …

Extracellular vesicles in NAFLD/ALD: from pathobiology to therapy

A Hernández, JP Arab, D Reyes, A Lapitz, H Moshage… - Cells, 2020 - mdpi.com
In recent years, knowledge on the biology and pathobiology of extracellular vesicles (EVs)
has exploded. EVs are submicron membrane-bound structures secreted from different cell …

Application of milk exosomes for musculoskeletal health: talking points in recent outcomes

NH Kim, J Kim, JY Lee, HA Bae, CY Kim - Nutrients, 2023 - mdpi.com
Milk is a nutrient-rich food source, and among the various milks, breast milk is a nutrient
source provided by mothers to newborns in many mammals. Exosomes are nano-sized …

Role of miRNA in the transmission of metabolic diseases associated with paternal diet-induced obesity

C Dupont, L Kappeler, S Saget, V Grandjean… - Frontiers in …, 2019 - frontiersin.org
The concept of Developmental Origins of Health and Diseases (DOHaD) recognizes that an
unfavorable maternal environment alters the developmental trajectory of the fetus and can …