Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

Naturalistic observations show that decisions to avoid or escape predators occur at different
spatiotemporal scales and that they are supported by different computations and neural …

Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric
condition. However, the biological mechanisms underlying this disease are still largely …

Numerous animal studies have demonstrated that fear acquisition and expression rely on
the coordinated activity of medial prefrontal cortex (mPFC) and amygdala and that theta …

The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

Post-traumatic stress disorder (PTSD) is a common, debilitating condition with limited
treatment options. Extinction of fear memories through prolonged exposure therapy, the …

Everyday life is defined by goal states that are continuously reprioritized based on available,
often affective information. To pursue these goals, individuals need to process and maintain …

Neural circuits underlying auditory fear conditioning have been extensively studied. Here we
identified a previously unexplored pathway from the lateral amygdala (LA) to the auditory …

Research over the past decade has provided strong support for the importance of various
epigenetic mechanisms, including DNA and histone modifications in regulating activity …