Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

[HTML][HTML] Understanding acquired brain injury: a review

L Goldman, EM Siddiqui, A Khan, S Jahan… - Biomedicines, 2022 - mdpi.com
Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI).
In general, ABI does not result from congenital disorders, degenerative diseases, or by brain …

Stroke research at a crossroad: asking the brain for directions

C Iadecola, J Anrather - Nature neuroscience, 2011 - nature.com
Ischemic stroke remains a vexing public health problem. Although progress has been made
in prevention and supportive care, efforts to protect the brain from ischemic cell death have …

[HTML][HTML] Roles of nitric oxide in brain ischemia and reperfusion

Y Wang, F Hong, S Yang - International journal of molecular sciences, 2022 - mdpi.com
Brain ischemia and reperfusion (I/R) is one of the most severe clinical manifestations of
ischemic stroke, placing a significant burden on both individuals and society. The only FDA …

Remote ischaemic conditioning—a new paradigm of self-protection in the brain

DC Hess, RA Blauenfeldt, G Andersen… - Nature Reviews …, 2015 - nature.com
Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

[HTML][HTML] Remote ischemic conditioning: from bench to bedside

SY Lim, DJ Hausenloy - Frontiers in physiology, 2012 - frontiersin.org
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue
against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an …

Effect of in-hospital remote ischemic perconditioning on brain infarction growth and clinical outcomes in patients with acute ischemic stroke: the RESCUE BRAIN …

F Pico, B Lapergue, M Ferrigno, C Rosso… - JAMA …, 2020 - jamanetwork.com
Importance Treatment with remote ischemic perconditioning has been reported to reduce
brain infarction volume in animal models of stroke. Whether this neuroprotective effect was …

[HTML][HTML] Blood pressure and penumbral sustenance in stroke from large vessel occlusion

RW Regenhardt, AS Das, CJ Stapleton… - Frontiers in …, 2017 - frontiersin.org
The global burden of stroke remains high, and of the various subtypes of stroke, large vessel
occlusions (LVOs) account for the largest proportion of stroke-related death and disability …

Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke

MN Hoda, S Siddiqui, S Herberg… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—Remote ischemic conditioning is cardioprotective in myocardial
infarction and neuroprotective in mechanical occlusion models of stroke. However, there is …

Remote ischemic conditioning for stroke: A critical systematic review

H Keevil, BE Phillips… - International Journal of …, 2024 - journals.sagepub.com
Remote ischemic conditioning (RIC) is the application of brief periods of ischemia to an
organ or tissue with the aim of inducing protection from ischemia in a distant organ. It was …