Role of polyphenols and other phytochemicals on molecular signaling

S Upadhyay, M Dixit - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
Optimized nutrition through supplementation of diet with plant derived phytochemicals has
attracted significant attention to prevent the onset of many chronic diseases including …

Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID‐19 therapy

V Citi, A Martelli, V Brancaleone, S Brogi… - British journal of …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐Cov‐2 demands rapid, safe and effective
therapeutic options. In the last decades, the endogenous gasotransmitter hydrogen sulfide …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020 - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

Sorting out the value of cruciferous sprouts as sources of bioactive compounds for nutrition and health

Á Abellán, R Domínguez-Perles, DA Moreno… - Nutrients, 2019 - mdpi.com
Edible sprouts with germinating seeds of a few days of age are naturally rich in nutrients and
other bioactive compounds. Among them, the cruciferous (Brassicaceae) sprouts stand out …

Cancer prevention with promising natural products: mechanisms of action and molecular targets

P Pratheeshkumar, C Sreekala, Z Zhang… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer is the second leading cause of death worldwide. There is greater need for more
effective and less toxic therapeutic and preventive strategies. Natural products are becoming …

Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice …

TY Wu, TO Khor, CLL Saw, SC Loh, AI Chen, SS Lim… - The AAPS journal, 2011 - Springer
Accumulating evidence from epidemiological studies indicates that chronic inflammation
and oxidative stress play critical roles in neoplastic development. The aim of this study was …

Health promoting effects of brassica‐derived phytochemicals: from chemopreventive and anti‐inflammatory activities to epigenetic regulation

AE Wagner, AM Terschluesen… - Oxidative medicine and …, 2013 - Wiley Online Library
A high intake of brassica vegetables may be associated with a decreased chronic disease
risk. Health promoting effects of Brassicaceae have been partly attributed to glucosinolates …

Biological targets of isothiocyanates

KK Brown, MB Hampton - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: Isothiocyanates are phytochemicals with a broad array of effects in
biological systems. Bioactivity includes the stimulation of cellular antioxidant systems …

Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo

SK Wang, TX Chen, W Wang, LL Xu, YQ Zhang… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Aesculetin (6, 7-dihydroxy-2H-1-benzopyran-2-
one) has been reported to exhibit potent anti-inflammatory property both in vitro and in vivo …

Isothiocyanates: Cholinesterase inhibiting, antioxidant, and anti-inflammatory activity

F Burčul, I Generalić Mekinić, M Radan… - Journal of enzyme …, 2018 - Taylor & Francis
Finding a new type of cholinesterase inhibitor that would overcome the brain availability and
pharmacokinetic parameters or hepatotoxic liability has been a focus of investigations …