Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …

Pancreatic ductal adenocarcinoma (PDA) was responsible for~ 44,000 deaths in the United
States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically …

The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …

The process of finding new therapeutic indications for currently used drugs, defined as
'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an …

Although nanomaterials have shown promising biomedical application potential, incomplete
understanding of their molecular interactions with biological systems prevents their inclusion …

Induction of cell death and inhibition of cell survival are the main principles of cancer
therapy. Resistance to chemotherapeutic agents is a major problem in oncology, which …

We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated
by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β) …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …