CD9 is a crucial regulator of cell adhesion in the immune system and plays important
physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is …

Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal
primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on …

While apolipoprotein E (apoE) expression by myeloid cells is recognized to control
inflammation, whether such benefits can be communicated via extracellular vesicles is not …

Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal
metastasis, a condition associated with a very poor prognosis. In these cancers, tumor …

CD47 regulates the trafficking of specific coding and noncoding RNAs into extracellular
vesicles (EVs), and the RNA contents of CD47+ EVs differ from that of CD63+ EVs released …

The cellular secretome is pivotal in mediating intercellular communication and coordinating
responses to stressors. Exosomes, initially recognized for their role in waste disposal, have …

Tetraspanin proteins organize membrane nanodomains related to cell adhesion and
migration. An essential feature conserved along the superfamily is their cone-shaped tertiary …

Immunotherapy, including immunostimulation and immunosuppression, has seen significant
development in the last 10 years. Immunostimulation has been verified as effective in anti …

We developed a novel asymmetric depth filtration (DF) approach to isolate extracellular
vesicles (EVs) from biological fluids that outperforms ultracentrifugation and size‐exclusion …

The tetraspanins CD9, CD81 and CD63 are major components of extracellular vesicles
(EVs). Yet, their impact on EV composition remains under‐investigated. In the MCF7 breast …