The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …

Background It has been known for close to a century that, on average, tumors have a
metabolism that is different from those found in healthy tissues. Typically, tumors show a …

Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …

The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine
kinase, which has a central function in integrating growth signals and orchestrating their …