Multi-target drugs for Alzheimer's disease

B Turgutalp, C Kizil - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Alzheimer's disease (AD), a leading cause of dementia, increasingly challenges our
healthcare systems and society. Traditional therapies aimed at single targets have fallen …

[HTML][HTML] Heterogeneous distribution of mitochondria and succinate dehydrogenase activity in human airway smooth muscle cells

SM Bhat, GC Sieck - FASEB BioAdvances, 2024 - ncbi.nlm.nih.gov
Succinate dehydrogenase (SDH) is a key mitochondrial enzyme involved in the tricarboxylic
acid cycle, where it facilitates the oxidation of succinate to fumarate, and is coupled to the …

[HTML][HTML] N-Acetylcysteine Attenuates Sepsis-Induced Muscle Atrophy by Downregulating Endoplasmic Reticulum Stress

R Chen, Y Zheng, C Zhou, H Dai, Y Wang, Y Chu… - Biomedicines, 2024 - mdpi.com
(1) Background: Sepsis-induced muscle atrophy is characterized by a loss of muscle mass
and function which leads to decreased quality of life and worsens the long-term prognosis of …