In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

1. INTRODUCTION A timely subtitle to this Review focused on conversions of isocyanides at
metal centers could have been “a platinum jubilee of the first metal-mediated reaction …

Pyrrole is one of the most important one-ring heterocycles. The ready availability of suitably
substituted and functionalized pyrrole derivatives is essential for the progress of many …

Conspectus The Passerini three-component (P-3CR) and the Ugi four-component (U-4CR)
are two of the most prominent isocyanide-based multicomponent reactions (IMCRs). The P …

INTRODUCTION The four-component Ugi reaction (Ugi-4CR) assembles peptide-like α-
acylaminoamides through one-pot reaction of a carbonyl compound, an amine, an acid, and …

Polyheterocycles are one of the most desired synthetic targets due to their numerous and
valuable applications in various fields. Multicomponent reactions (MCRs) are highly …

Isocyanides have been important building blocks in synthetic chemistry since the discovery
of the Ugi reaction and related multicomponent reactions.[1] Isocyanides are isoelectronic …

Multicomponent reactions (MCRs) undoubtedly correspond to one of the synthetic strategies
that best fit the new demands of chemistry for presenting high atom economy and enabling …

Isocyanide-based multicomponent reactions in the synthesis of heterocycles - RSC Advances
(RSC Publishing) DOI:10.1039/C6RA02143C Royal Society of Chemistry View PDF …

Multicomponent reactions–reactions that combine three or more starting materials in one pot
to give a single product that contains essentially all of the atoms of the reactants–offer many …