Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Formins are highly conserved proteins that have essential roles in remodelling the actin and
microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work …

Higher vertebrates have 3 Rho GTPases, RhoA, RhoB, and RhoC, which share 85% amino
acid sequence identity. Here, we compare and contrast the roles of RhoA, B, and C in the …

Wound healing involves a coordinated series of tissue movements that bears a striking
resemblance to various embryonic morphogenetic episodes. There are several ways in …

We investigated the forces that connect the genetic program of development to
morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for …

The capacity to repair a wound is a fundamental survival mechanism that is activated at any
site of damage throughout embryonic and adult life. To study the cell biology and genetics of …

One of the principal functions of any epithelium in the embryonic or adult organism is to act
as a self-sealing barrier layer. From the earliest stages of development, embryonic epithelia …

E-cadherin plays a pivotal role in epithelial morphogenesis. It controls the intercellular
adhesion required for tissue cohesion and anchors the actomyosin-driven tension needed to …

Epithelial cell–cell junctions are formed by apical adherens junctions (AJs), which are
composed of cadherin adhesion molecules interacting in a dynamic way with the cortical …