The serum-and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and
under genomic control by cell stress (including cell shrinkage) and hormones (including …

The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

The fluid in the 14 distinct segments of the renal tubule undergoes sequential transport
processes that gradually convert the glomerular filtrate into the final urine. The solute carrier …

▪ Abstract The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the
regulation of epithelial ion transport. This kinase is very rapidly regulated at the …

Epithelial Na+ transport is regulated in large part by mechanisms that control expression of
the epithelial Na+ channel (ENaC) at the cell surface. Nedd4 and Nedd4-2 are candidates to …

Amiloride-sensitive Na+ channel activity was examined in the cortical collecting ducts of a
mouse line (SGK1−/−) deficient in the serum-and glucocorticoid-dependent protein kinase …

WNK1 belongs to a unique family of Ser/Thr kinases that have been implicated in the control
of blood pressure. Intronic deletions in the WNK1 gene result in its overexpression and lead …

Aldosterone plays a central role in Na+ homeostasis by controlling Na+ reabsorption in the
aldosterone-sensitive distal nephron involving the epithelial Na+ channel (ENaC). Part of …

Recent clinical studies demonstrated beneficial effects of mineralocorticoid receptor (MR)
antagonists in patients with heart failure and other cardiovascular diseases. However, the …

Members of the serum-and glucocorticoid-regulated kinase (SGK) family are important
mediators of growth factor and hormone signaling that, like their close relatives in the Akt …