Carbohydrates are a fundamental unit playing pivotal roles in all the biological processes. It
is thus essential to develop methods for synthesizing, functionalizing, and manipulating …

Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are
reviewed. The construction of oligosaccharides of defined connectivity hinges on such …

The divergent total syntheses of complex natural products from a common intermediate have
attracted enormous attention in the chemical community in the past few years because it can …

Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …

Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent
interactions such as hydrogen bonds and ion pairs can act as powerful controllers of …

The application of small molecules as catalysts for the diversification of natural product
scaffolds is reviewed. Specifically, principles that relate to the selectivity challenges intrinsic …

Many organisms use sugars as building blocks for more complex structures in nature such
as cellulose in plants and chitin in crustaceans. To construct these large polysaccharides …

Total synthesis is frequently compared to climbing as it provides a suitable route to reach a
high point from the floor, the complex natural product from simple and commercially …

The growing emphasis on macrocycles in engaging difficult therapeutic targets such as
protein–protein interactions and GPCRs via preferential adaptation of bioactive and cell …

Chemical synthesis or modification of saccharides remains a major challenge largely
because site-selective reactions on their many similar hydroxyl groups are difficult. The lack …