Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder characterized by left
ventricular hypertrophy, hyperdynamic contraction, and impaired relaxation of the heart …
ventricular hypertrophy, hyperdynamic contraction, and impaired relaxation of the heart …
Regulating striated muscle contraction: Through thick and thin
E Brunello, L Fusi - Annual Review of Physiology, 2024 - annualreviews.org
Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …
containing thin filaments triggered by an increase in intracellular calcium concentration …
Cryo-EM structure of the human cardiac myosin filament
Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force
Contraction in striated muscle is initiated by calcium binding to troponin complexes, but it is
now understood that dynamic transition of myosin between resting, ordered OFF states on …
now understood that dynamic transition of myosin between resting, ordered OFF states on …
Cardiac myosin contraction and mechanotransduction in health and disease
SK Barrick, MJ Greenberg - Journal of Biological Chemistry, 2021 - ASBMB
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
Structural basis of the super-and hyper-relaxed states of myosin II
Super-relaxation is a state of muscle thick filaments in which ATP turnover by myosin is
much slower than that of myosin II in solution. This inhibited state, in equilibrium with a faster …
much slower than that of myosin II in solution. This inhibited state, in equilibrium with a faster …
Titin force in muscle cells alters lattice order, thick and thin filament protein formation
Skeletal muscle force production is increased at longer compared to shorter muscle lengths
because of length-dependent priming of thick filament proteins in the contractile unit before …
because of length-dependent priming of thick filament proteins in the contractile unit before …
Small angle X-ray diffraction as a tool for structural characterization of muscle disease
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …
structural information from striated muscle fibers under hydrated physiological conditions …
Cardiac myosin filaments are directly regulated by calcium
Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …
Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads
Muscle contraction is produced via the interaction of myofilaments and is regulated so that
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …