Symbionts and gene drive: two strategies to combat vector-borne disease
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
[HTML][HTML] Synthetic biology tools for environmental protection
Synthetic biology transforms the way we perceive biological systems. Emerging
technologies in this field affect many disciplines of science and engineering. Traditionally …
technologies in this field affect many disciplines of science and engineering. Traditionally …
CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii
AK Yadav, C Butler, A Yamamoto… - Proceedings of the …, 2023 - National Acad Sciences
Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
Incorporating ecology into gene drive modelling
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …
wild populations, represents a promising new tool in the fight against vector‐borne diseases …
[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …
spread throughout a population. They could potentially be used to modify or suppress pest …
[HTML][HTML] Review of gene drive modelling and implications for risk assessment of gene drive organisms
JL Frieß, CR Lalyer, B Giese, S Simon, M Otto - Ecological Modelling, 2023 - Elsevier
Synthetic gene drive (GD) systems constitute a form of novel invasive environmental
biotechnology with far-reaching consequences beyond those of other known genetically …
biotechnology with far-reaching consequences beyond those of other known genetically …
Experimental demonstration of tethered gene drive systems for confined population modification or suppression
Background Homing gene drives hold great promise for the genetic control of natural
populations. However, current homing systems are capable of spreading uncontrollably …
populations. However, current homing systems are capable of spreading uncontrollably …
Gene drive strategies of pest control in agricultural systems: Challenges and opportunities
Recent advances in gene‐editing technologies have opened new avenues for genetic pest
control strategies, in particular around the use of gene drives to suppress or modify pest …
control strategies, in particular around the use of gene drives to suppress or modify pest …
Engineering the composition and fate of wild populations with gene drive
BA Hay, G Oberhofer, M Guo - Annual Review of Entomology, 2021 - annualreviews.org
Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …
sources of economically important products. They can also destroy crops; wound animals; …
Next-generation CRISPR gene-drive systems using Cas12a nuclease
S Sanz Juste, EM Okamoto, C Nguyen, X Feng… - Nature …, 2023 - nature.com
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-
based gene drives, which manipulate insect populations due to their ability to rapidly …
based gene drives, which manipulate insect populations due to their ability to rapidly …