Symbionts and gene drive: two strategies to combat vector-borne disease

GH Wang, J Du, CY Chu, M Madhav, GL Hughes… - Trends in Genetics, 2022 - cell.com
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

[HTML][HTML] Synthetic biology tools for environmental protection

J Aminian-Dehkordi, S Rahimi, M Golzar-Ahmadi… - Biotechnology …, 2023 - Elsevier
Synthetic biology transforms the way we perceive biological systems. Emerging
technologies in this field affect many disciplines of science and engineering. Traditionally …

CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii

AK Yadav, C Butler, A Yamamoto… - Proceedings of the …, 2023 - National Acad Sciences
Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …

Incorporating ecology into gene drive modelling

J Kim, KD Harris, IK Kim, S Shemesh… - Ecology …, 2023 - Wiley Online Library
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …

[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

E Yang, M Metzloff, AM Langmüller, X Xu, AG Clark… - G3, 2022 - academic.oup.com
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …

[HTML][HTML] Review of gene drive modelling and implications for risk assessment of gene drive organisms

JL Frieß, CR Lalyer, B Giese, S Simon, M Otto - Ecological Modelling, 2023 - Elsevier
Synthetic gene drive (GD) systems constitute a form of novel invasive environmental
biotechnology with far-reaching consequences beyond those of other known genetically …

Experimental demonstration of tethered gene drive systems for confined population modification or suppression

M Metzloff, E Yang, S Dhole, AG Clark, PW Messer… - BMC biology, 2022 - Springer
Background Homing gene drives hold great promise for the genetic control of natural
populations. However, current homing systems are capable of spreading uncontrollably …

Gene drive strategies of pest control in agricultural systems: Challenges and opportunities

M Legros, JM Marshall, S Macfadyen… - Evolutionary …, 2021 - Wiley Online Library
Recent advances in gene‐editing technologies have opened new avenues for genetic pest
control strategies, in particular around the use of gene drives to suppress or modify pest …

Engineering the composition and fate of wild populations with gene drive

BA Hay, G Oberhofer, M Guo - Annual Review of Entomology, 2021 - annualreviews.org
Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …

Next-generation CRISPR gene-drive systems using Cas12a nuclease

S Sanz Juste, EM Okamoto, C Nguyen, X Feng… - Nature …, 2023 - nature.com
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-
based gene drives, which manipulate insect populations due to their ability to rapidly …