Shifting the limits in wheat research and breeding using a fully annotated reference genome
International Wheat Genome Sequencing Consortium … - Science, 2018 - science.org
INTRODUCTION Wheat (Triticum aestivum L.) is the most widely cultivated crop on Earth,
contributing about a fifth of the total calories consumed by humans. Consequently, wheat …
contributing about a fifth of the total calories consumed by humans. Consequently, wheat …
Rational discovery of molecular glue degraders via scalable chemical profiling
C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka… - Nature chemical …, 2020 - nature.com
Targeted protein degradation is a new therapeutic modality based on drugs that destabilize
proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are …
proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are …
Whole-genome annotation with BRAKER
BRAKER is a pipeline for highly accurate and fully automated gene prediction in novel
eukaryotic genomes. It combines two major tools: GeneMark-ES/ET and AUGUSTUS …
eukaryotic genomes. It combines two major tools: GeneMark-ES/ET and AUGUSTUS …
[HTML][HTML] BCG vaccination induces long-term functional reprogramming of human neutrophils
SJ Moorlag, YA Rodriguez-Rosales, J Gillard… - Cell reports, 2020 - cell.com
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some
heterologous infections, probably via induction of non-specific innate immune memory in …
heterologous infections, probably via induction of non-specific innate immune memory in …
BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial
effects against non-related infections. The basis of these effects has been poorly explored in …
effects against non-related infections. The basis of these effects has been poorly explored in …
Multi-platform discovery of haplotype-resolved structural variation in human genomes
The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a …
data limits studies of human genetic diversity and disease association. Here, we apply a …
Metabolic induction of trained immunity through the mevalonate pathway
Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …
during infections or vaccinations. Here, we report that metabolic signals can induce trained …
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
INTRODUCTION Aneuploidy, also known as somatic copy number alterations (SCNAs), is
widespread in human cancers and has been proposed to drive tumorigenesis. The …
widespread in human cancers and has been proposed to drive tumorigenesis. The …
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Targeted protein degradation is a novel pharmacology established by drugs that recruit
target proteins to E3 ubiquitin ligases. Based on the structure of the degrader and the target …
target proteins to E3 ubiquitin ligases. Based on the structure of the degrader and the target …
Inherited and de novo genetic risk for autism impacts shared networks
We performed a comprehensive assessment of rare inherited variation in autism spectrum
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …