Nitric oxide in health and disease of the respiratory system

FLM Ricciardolo, PJ Sterk, B Gaston… - Physiological …, 2004 - journals.physiology.org
During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

Inflammatory mediators of asthma: an update

PJ Barnes, KF Chung, CP Page - Pharmacological reviews, 1998 - ASPET
Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Multiple roles of nitric oxide in the airways

FLM Ricciardolo - Thorax, 2003 - thorax.bmj.com
Nitric oxide is endogenously released in the airways by nitric oxide synthase. Functionally,
two isoforms of this enzyme exist: constitutive and inducible. The former seems to protect …

Sex steroid signaling: implications for lung diseases

V Sathish, YN Martin, YS Prakash - Pharmacology & therapeutics, 2015 - Elsevier
There is increasing recognition that sex hormones (estrogen, progesterone, and
testosterone) have biological and pathophysiological actions in peripheral, non-reproductive …

Reflex regulation of airway smooth muscle tone

BJ Canning - Journal of applied physiology, 2006 - journals.physiology.org
Autonomic nerves in most mammalian species mediate both contractions and relaxations of
airway smooth muscle. Cholinergic-parasympathetic nerves mediate contractions, whereas …

Reactive nitrogen species in the respiratory tract

FLM Ricciardolo, A Di Stefano, F Sabatini… - European journal of …, 2006 - Elsevier
Endogenous Nitric Oxide (NO) plays a key role in the physiological regulation of airway
functions. In response to various stimuli activated inflammatory cells (eg, eosinophils and …

Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels

H Kuriyama, K Kitamura, T Itoh… - Physiological …, 1998 - journals.physiology.org
Kuriyama, H., K. Kitamura, T. Itoh, and R. Inoue. Physiological Features of Visceral Smooth
Muscle Cells, With Special Reference to Receptors and Ion Channels. Physiol. Rev. 78: 811 …

A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics

TT Hansel, SA Kharitonov, LE Donnelly… - The FASEB …, 2003 - Wiley Online Library
The inducible isoenzyme of nitric oxide synthase (iNOS) generates nitric oxide (NO) in
inflammatory diseases such as asthma. The prodrug L‐N6‐(1‐iminoethyl) lysine 5‐tetrazole …

Exhaled nitric oxide: a new lung function test.

PJ Barnes, SA Kharitonov - Thorax, 1996 - ncbi.nlm.nih.gov
Nitric oxide (NO) is produced by many cells within the respiratorytract and endogenous NO
may playan important signalling role in the physiological control ofairway function and in the …

Autonomic innervation of human airways: structure, function, and pathophysiology in asthma

VHJ Van der Velden, AR Hulsmann - Neuroimmunomodulation, 1999 - karger.com
The human airways are innervated via efferent and afferent autonomic nerves, which
regulate many aspects of airway function. It has been suggested that neural control of the …