Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular
glucose usage. The upregulation of GLUT s has been reported in numerous cancer types as …

Plumbagin (PLB), a natural naphthoquinone constituent isolated from the roots of the
medicinal plant Plumbago zeylanica L., exhibited anticancer activity against a variety of …

There is close crosstalk between cancer metabolism and immunity. Cancer metabolism
regulation is a promising therapeutic target for cancer immunotherapy. Warburg effect is …

Oncogene-driven metabolic rewiring is an adaptation to low nutrient and oxygen conditions
in the tumor microenvironment that enables cancer cells of diverse origin to hyperproliferate …

Cutaneous melanoma (CM) is a highly aggressive and drug resistant solid tumor, showing
an impressive metabolic plasticity modulated by oncogenic activation. In particular …

Glucose addiction is observed in cancer and other diseases that are associated with
hyperproliferation. The development of compounds that restrict glucose supply and …

Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …

Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant
solid tumors. CM is characterized by a remarkable metabolic plasticity and an important …

DNA repair and metabolic pathways are vital to maintain cellular homeostasis in normal
human cells. Both of these pathways, however, undergo extensive changes during …

Over the past decades, melanoma-related mortality has remained nearly stable. The main
reason is treatment failure of metastatic disease and the inherently linked knowledge gap …