Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …

ABSTRACT SQ109, a 1, 2-diamine related to ethambutol, is currently in clinical trials for the
treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that …

Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside
its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Recent evidence shows that mycobacteria have developed novel and specialized secretion
systems for the transport of extracellular proteins across their hydrophobic, and highly …

Background Mycobacterium tuberculosis is the principal etiologic agent of human
tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous
disease states. Despite its importance, the ability to study metabolism at a global scale using …

The cell envelope of mycobacteria, which include the causative agents of tuberculosis and
leprosy, is crucial for their success as pathogens. Despite a continued strong emphasis on …