Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

Coagulopathy is a severe and frequent complication in critically ill patients, for which the
pathogenesis and presentation may be variable depending on the underlying disease …

Extracellular matrix (ECM) maintains the structural integrity of tissues and regulates cell and
tissue functions. ECM is comprised of fibrillar proteins, proteoglycans (PGs) …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

The skeletal muscle is a metabolically active tissue that secretes various proteins. These so-
called myokines have been proposed to affect muscle physiology and to exert systemic …

Cancer cells show constitutive upregulation of glycolysis, and the concentration of lactate
thus produced correlates with prognosis. Here, we examined whether lactate concentration …

Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …

Background Information: Previous studies have revealed that leptin may be involved in
epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate …