TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

M Di Rienzo, A Romagnoli, M Antonioli… - Cell Death & …, 2020 - nature.com
Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The tripartite nexus: autophagy, cancer, and tripartite motif-containing protein family members

MA Mandell, B Saha, TA Thompson - Frontiers in pharmacology, 2020 - frontiersin.org
Autophagy is a cellular degradative process that has multiple important actions in cancer.
Autophagy modulation is under consideration as a promising new approach to cancer …

RREB1 regulates neuronal proteostasis and the microtubule network

EN Griffin, T Jucius, SE Sim, BS Harris, S Heinz… - Science …, 2024 - science.org
Transcription factors play vital roles in neuron development; however, little is known about
the role of these proteins in maintaining neuronal homeostasis. Here, we show that the …

TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis

Y Yang, Y Zhu, S Zhou, P Tang, R Xu, Y Zhang… - The EMBO …, 2022 - embopress.org
Autophagy represents a fundamental mechanism for maintaining cell survival and tissue
homeostasis in response to physiological and pathological stress. Autophagy initiation …

The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages

A Romagnoli, M Di Rienzo, E Petruccioli, C Fusco… - Cell Death & …, 2023 - nature.com
Mycobacterium tuberculosis (Mtb) is known to evade host immune responses and persist in
macrophages for long periods. A mechanism that the host uses to combat Mtb is xenophagy …

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1

H Heo, H Park, MS Lee, J Kim, J Kim, SY Jung… - Autophagy, 2024 - Taylor & Francis
Tripartite motif (TRIM) proteins are a large family of E3 ubiquitin ligases implicated in
antiviral defense systems, tumorigenesis, and protein quality control. TRIM proteins …

TRIMming down to TRIM37: relevance to inflammation, cardiovascular disorders, and cancer in MULIBREY nanism

B Brigant, V Metzinger-Le Meuth, J Rochette… - International Journal of …, 2018 - mdpi.com
TRIpartite motif (TRIM) proteins are part of the largest subfamilies of E3 ligases that mediate
the transfer of ubiquitin to substrate target proteins. In this review, we focus on TRIM37 in the …

Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR‐1236‐3p/TRIM37 axis

TF Song, AL Xu, XH Chen, JY Gao… - … Kaohsiung Journal of …, 2021 - Wiley Online Library
Circular RNAs (circRNAs) appear to be significant modulators in various physiological
processes. Recently, it is found that circRNA_101996 exerts important roles in various …

Autophagy in cancer: The cornerstone during glutamine deprivation

HM Fares, X Lyu, X Xu, R Dong, M Ding, S Mi… - European Journal of …, 2022 - Elsevier
Over the past two decades, researchers have revealed the crucial functions of glutamine in
supporting the hyperproliferation state of cancer cells. Glutamine acts on maintaining high …