Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts
S Quek, A Hadermann, Y Wu, L De Coninck… - Nature …, 2024 - nature.com
Parasitic nematodes have an intimate, chronic and lifelong exposure to vertebrate tissues.
Here we mined 41 published parasitic nematode transcriptomes from vertebrate hosts and …
Here we mined 41 published parasitic nematode transcriptomes from vertebrate hosts and …
Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes
NJ Wheeler, ZW Heimark, PM Airs, A Mann… - PLoS …, 2020 - journals.plos.org
Lymphatic filariasis (LF) afflicts over 60 million people worldwide and leads to severe
pathological outcomes in chronic cases. The nematode parasites (Nematoda: Filarioidea) …
pathological outcomes in chronic cases. The nematode parasites (Nematoda: Filarioidea) …
Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi
Lymphatic filariasis (LF) is a chronic debilitating neglected tropical disease (NTD) caused by
mosquito-transmitted nematodes that afflicts over 60 million people. Control of LF relies on …
mosquito-transmitted nematodes that afflicts over 60 million people. Control of LF relies on …
Improved metagenome assemblies through selective enrichment of bacterial genomic DNA from eukaryotic host genomic DNA using ATAC-seq
LJ Cantin, JC Dunning Hotopp, JM Foster - Frontiers in Microbiology, 2024 - frontiersin.org
Genomics can be used to study the complex relationships between hosts and their
microbiota. Many bacteria cannot be cultured in the laboratory, making it difficult to obtain …
microbiota. Many bacteria cannot be cultured in the laboratory, making it difficult to obtain …
Updated annotation and meta-analysis of Brugia malayi transcriptomics data reveals consistent transcriptional profiles across time and space with some study …
CI Holt, JC Dunning Hotopp - PLOS Neglected Tropical Diseases, 2024 - journals.plos.org
Genomics, transcriptomics, and proteomics have significantly advanced our understanding
of obligately host-associated microbes, where interrogation of the biology is often limited by …
of obligately host-associated microbes, where interrogation of the biology is often limited by …
Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons
Filarial parasitic nematodes (Filarioidea) cause substantial disease burden to humans and
animals around the world. Recently there has been a coordinated global effort to generate …
animals around the world. Recently there has been a coordinated global effort to generate …
Defining the filarial N-glycoproteome by glycosite mapping in the human parasitic nematode Brugia malayi
FB Mersha, CM McClung, M Chen, CI Ruse… - Scientific Reports, 2023 - nature.com
N-linked glycosylation is a critical post translational modification of eukaryotic proteins. N-
linked glycans are present on surface and secreted filarial proteins that play a role in host …
linked glycans are present on surface and secreted filarial proteins that play a role in host …
Drug repurposing of bromodomain inhibitors as potential novel therapeutic leads for lymphatic filariasis guided by multispecies transcriptomics
To better understand the transcriptomic interplay of organisms associated with lymphatic
filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial …
filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial …
SMC-mediated dosage compensation in C. elegans evolved in the presence of an ancestral nematode mechanism
A Aharonoff, J Kim, A Washington, S Ercan - bioRxiv, 2024 - biorxiv.org
Mechanisms of X chromosome dosage compensation have been studied extensively in a
few model species representing clades of shared sex chromosome ancestry. However, the …
few model species representing clades of shared sex chromosome ancestry. However, the …
[PDF][PDF] The RNA virome of human and animal parasitic nematodes
S Quek, A Hadermann, Y Wu… - Research …, 2023 - assets-eu.researchsquare.com
Screening published transcriptomes, we have discovered 75 RNA viruses that infect 27
species of parasitic nematodes, responsible for> 1.5 billion infections in people and animals …
species of parasitic nematodes, responsible for> 1.5 billion infections in people and animals …