Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …

Mycobacterium tuberculosis infects primarily macrophages in the lungs. Infected
macrophages are surrounded by other immune cells in well organised structures called …

Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these
diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which …

Tuberculosis (TB) is one of the leading causes of death worldwide, consistently threatening
public health. Conventional tuberculosis treatment requires a long-term treatment regimen …

Lipid droplets (LDs) are dynamic and versatile organelles present in most eukaryotic cells.
LDs consist of a hydrophobic core of neutral lipids, a phospholipid monolayer coat, and a …

Background Increasing prevalence of drug-resistant tuberculosis (DR-TB) poses a major
challenge to the early detection and effective control of tuberculosis (TB). Exosomes carrying …

The discovery of molecules that could shorten the treatment period of tuberculosis (TB)
holds the promise of improving the current regimen. Polyamines are organic polycationic …

Science has been taking profit from animal models since the first translational experiments
back in ancient Greece. From there, and across all history, several remarkable findings have …

Host–pathogen interactions are shaped by the metabolic status of both the host and
pathogen. The host must regulate metabolism to fuel the immune response, while the …

Infection with Mycobacterium tuberculosis leads to the development of tuberculosis (TB) with
the formation of granulomatous lesions. Foamy macrophages (FM) are a hallmark of TB …