[HTML][HTML] Mechanism of metformin regulation in central nervous system: Progression and future perspectives

G Cao, T Gong, Y Du, Y Wang, T Ge, J Liu - Biomedicine & …, 2022 - Elsevier
Metformin as a first-line drug for type 2 diabetes mellitus (T2DM) treatment is widely studied.
Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence …

[HTML][HTML] A review on role of metformin as a potential drug for epilepsy treatment and modulation of epileptogenesis

R Singh, SC Sarangi, S Singh, M Tripathi - Seizure, 2022 - Elsevier
Background Available anti-seizure medications (ASMs) target the symptomatology of the
disease rather than any significant disease/epileptogenesis modifying actions. There are …

Beneficial effects of metformin on the central nervous system, with a focus on epilepsy and Lafora disease

P Sanz, JM Serratosa, MP Sánchez - International Journal of Molecular …, 2021 - mdpi.com
Metformin is a drug in the family of biguanide compounds that is widely used in the treatment
of type 2 diabetes (T2D). Interestingly, the therapeutic potential of metformin expands its …

Alpha-pinene exerts antiseizure effects by preventing oxidative stress and apoptosis in the hippocampus in a rat model of temporal lobe epilepsy induced by kainate

P Hashemi, S Ahmadi - Molecular Neurobiology, 2023 - Springer
Oxidative stress and apoptosis following seizures play pivotal roles in the consequences of
repeated seizures. Beneficial effects of alpha-pinene (APN) have been reported in some …

A mechanism of action of Metformin in the brain: Prevention of Methylglyoxal-Induced glutamatergic impairment in Acute hippocampal slices

AFK Vizuete, F Fróes, M Seady, F Hansen… - Molecular …, 2024 - Springer
Metformin, a biguanide compound (N-1, 1-dimethylbiguanide), is widely prescribed for
diabetes mellitus type 2 (T2D) treatment. It also presents a plethora of properties, such as …

Anticonvulsant effects of royal jelly in kainic acid-induced animal model of temporal lobe epilepsy through antioxidant activity

P Hashemi, MR Moloudi, Z Vahabzadeh… - Neurochemical …, 2023 - Springer
Temporal lobe epilepsy (TLE) is the most common form of partial and drug-resistant
epilepsy, characterized by recurrent seizures originating from temporal lobe structures like …

Proliferative cells in racemose neurocysticercosis have an active MAPK signalling pathway and respond to metformin treatment

MA Orrego, MR Verastegui, CM Vasquez… - International journal for …, 2022 - Elsevier
Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion
of the cyst form of Taenia solium within the subarachnoid spaces of the human brain and …

AMPK role in epilepsy: a promising therapeutic target?

Y Qi, Y Zhang, Y Gao, W Chen, T Zhou, L Chang… - Journal of …, 2024 - Springer
Epilepsy is a complex and multifaceted neurological disorder characterized by spontaneous
and recurring seizures. It poses significant therapeutic challenges due to its diverse etiology …

Investigating the mechanism of antiepileptogenic effect of apigenin in kainate temporal lobe epilepsy: Possible role of mTOR

F Nikbakht, P Hashemi, S Vazifekhah… - Experimental brain …, 2023 - Springer
Clarifying the underlying mechanisms of epileptogenesis is important in preventing the
progression of chronic epilepsy. In epilepsy, the mTOR (mammalian target of rapamycin) …

[HTML][HTML] Alpha-Pinene Effect on the Improvement of Working and Spatial memory in Rats

P Hashemi, H Rahmani, MR Moloudi… - Scientific Journal of …, 2023 - sjku.muk.ac.ir
Materials and Methods: In this study, 24 male rats were randomly divided into 3 groups:
control and 2 alpha-pinene groups (5 and 10 mg/kg IP) for 3 weeks. Spatial and working …