[HTML][HTML] From reads to insight: a hitchhiker's guide to ATAC-seq data analysis
Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …
used in studying chromatin biology, but a comprehensive review of the analysis tools has …
[HTML][HTML] Computational oncology in the multi-omics era: state of the art
G de Anda-Jáuregui, E Hernández-Lemus - Frontiers in oncology, 2020 - frontiersin.org
Cancer is the quintessential complex disease. As technologies evolve faster each day, we
are able to quantify the different layers of biological elements that contribute to the …
are able to quantify the different layers of biological elements that contribute to the …
[HTML][HTML] Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …
immune cells of this organ. Microglial features are strongly dependent on environmental …
FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development
N 6-methyladenosine (m6A) is the most abundant internal modification on mammalian
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
LA Farrelly, RE Thompson, S Zhao, AE Lepack, Y Lyu… - Nature, 2019 - nature.com
Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription,–. Here we provide evidence for a class of histone post …
including gene transcription,–. Here we provide evidence for a class of histone post …
[HTML][HTML] Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA
WC Hao, MJ Dian, Y Zhou, QL Zhong, WQ Pang… - Nature …, 2022 - nature.com
Autophagy is crucial for maintaining cellular energy homeostasis and for cells to adapt to
nutrient deficiency, and nutrient sensors regulating autophagy have been reported …
nutrient deficiency, and nutrient sensors regulating autophagy have been reported …
[HTML][HTML] METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding
The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in
cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive …
cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive …
[HTML][HTML] Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells
Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC
compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but …
compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but …
[HTML][HTML] WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis
FTO removes the N6-methyladenosine (m6A) modification from genes and plays a critical
role in cancer development. However, the mechanisms underlying the regulation of FTO and …
role in cancer development. However, the mechanisms underlying the regulation of FTO and …
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …