Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of
autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which …

Skin is our primary interface with the environment, and T cells are crucial for orchestrating
host immune responses against pathogenic microorganisms at this site. Effective skin …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Tissue-resident memory T cells (TRM) persist locally in nonlymphoid tissues where they
provide frontline defense against recurring insults. TRM at barrier surfaces express the …

Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …