Abstract β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the β-secretase
enzyme required for the production of the neurotoxic β-amyloid (Aβ) peptide that is widely …

As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been
identified as the constitutive α-secretase in the process of amyloid-β protein precursor …

Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …

Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people
around the world. The two main pathological mechanisms underlying the disease are beta …

Introduction: BACE 1 is a protease that cleaves the transmembrane amyloid precursor
protein and generates amyloid-β peptides that accumulate in AD brains. No known …

We have previously reported that low doses of external beam ionizing irradiation reduced
amyloid-ß (Aß) plaques and improved cognition in APP/PS1 mice. In this study we …

Accumulating evidence points to the amyloid-β (Aβ) peptide as the culprit in the
pathogenesis of Alzheimer's disease (AD). β-Site amyloid precursor protein (APP)-cleaving …

Abstract Alzheimer's disease (AD), the prevalent dementia in the elderly, involves many
related and interdependent pathologies that manifests simultaneously, eventually leading to …

Clivia miniata (Lindl) is a member of the family Amaryllidaceae known for its chemically
diverse alkaloids with a wide range of biological activities. Many reports revealed a direct …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease and it is the most
common adult onset neurodegenerative disorder affecting motor neurons. There is currently …