Ongoing efforts to generate a complete and accurate annotation of the genome have
revealed a significant blind spot for small proteins (< 100 amino acids) originating from short …

Thousands of unannotated small and alternative open reading frames (smORFs and alt-
ORFs, respectively) have recently been revealed in mammalian genomes. While hundreds …

Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …

Proteinaceous cysteines function as essential sensors of cellular redox state. Consequently,
defining the cysteine redoxome is a key challenge for functional proteomic studies. While …

A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …

The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and
outside the nucleus. However, it is currently unclear whether and how the distribution of …

In the decades following the discovery that genes encode proteins, scientists have tried to
exhaustively and comprehensively characterize the human genome. Recent advances in …

Advances in proteogenomic technologies have revealed hundreds to thousands of
translated small open reading frames (sORFs) that encode microproteins in genomes across …

Microproteins encoded by small open reading frames (sORFs) have emerged as a
fascinating frontier in genomics. Traditionally overlooked due to their small size, recent …

Ribosomal frameshifting refers to the process that ribosomes slip into+ 1 or− 1 reading
frame, thus produce chimeric trans-frame proteins. In viruses and bacteria, programmed …