NMR-based metabolomics applied to ecotoxicology with zebrafish (Danio rerio) as a prominent model for metabolic profiling and biomarker discovery: Overviewing …

VA Porto, ER da Rocha Júnior, JS Ursulino… - Science of The Total …, 2023 - Elsevier
Metabolomics is an innovative approach used in the medical, toxicological, and biological
sciences. As an interdisciplinary topic, metabolomics and its relation with the environment …

Recent development in zebrafish model for bioactivity and safety evaluation of natural products

FJ Lin, H Li, DT Wu, QG Zhuang, HB Li… - Critical Reviews in …, 2022 - Taylor & Francis
The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several
advantageous features have facilitated zebrafish to be extensively utilized as a valuable …

Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from Cannabis sativa L. Promising Compounds?

E Nigro, M Formato, G Crescente, A Daniele - Molecules, 2021 - mdpi.com
Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids
that are receiving renewed interest due to their diverse pharmacologic activities. Indeed …

Toxicological evaluation and pain assessment of four minor cannabinoids following 14-day oral administration in rats

J Kulpa, RG Henderson, D Schwotzer… - Cannabis and …, 2023 - liebertpub.com
Introduction: Despite growing consumer interest and market availability, the safety of minor
cannabinoids, generally present in low concentrations in Cannabis sativa L., is not well …

An efficient and simple SERS approach for trace analysis of tetrahydrocannabinol and cannabinol and multi-cannabinoid detection

R Botta, S Limwichean, N Limsuwan, C Moonlek… - … Acta Part A: Molecular …, 2022 - Elsevier
Many countries have legalized cannabis and its derived products for multiple purposes.
Consequently, it has become necessary to develop a rapid, effective, and reliable tool for …

Tralopyril affects locomotor activity of zebrafish (Danio rerio) by impairing tail muscle tissue, the nervous system, and energy metabolism

X Chen, J Zheng, M Teng, J Zhang, L Qian, M Duan… - Chemosphere, 2022 - Elsevier
Tralopyril (TP), an antifouling biocide, is widely used to prevent heavy biofouling, and can
have potential risks to aquatic organisms. In this study, the effect of TP on locomotor activity …

Geosmin disrupts energy metabolism and locomotor behavior of zebrafish in early life stages

W Zhou, Y Wang, J Wang, C Peng, Z Wang… - Science of the Total …, 2023 - Elsevier
Geosmin has been commonly detected both in various aquatic environments and biota, but
its exact toxicological mechanisms to organisms need further experimentation. In the present …

Mass spectrometry-based zebrafish toxicometabolomics: a review of analytical and data quality challenges

KM da Silva, E Iturrospe, C Bars, D Knapen… - Metabolites, 2021 - mdpi.com
Metabolomics has achieved great progress over the last 20 years, and it is currently
considered a mature research field. As a result, the number of applications in toxicology …

Alternative model organisms for toxicological fingerprinting of relevant parameters in food and nutrition

G Sandner, A König, M Wallner… - Critical reviews in food …, 2022 - Taylor & Francis
In the field of (food) toxicology, there is a strong trend of replacing animal trials with
alternative methods for the assessment of adverse health effects in humans. The …

A review on the bioactivity of cannabinoids on zebrafish models: Emphasis on neurodevelopment

R Licitra, M Marchese, V Naef, A Ogi, M Martinelli… - Biomedicines, 2022 - mdpi.com
For centuries, the cannabis plant has been used as a source of food, fiber, and medicine.
Recently, scientific interest in cannabis has increased considerably, as its bioactive …