Adults express two isoforms of glutamate decarboxylase (GAD), GAD67 and GAD65, which
are encoded by different independently regulated genes, a situation that differs from that of …

Glutamic acid is an amino acid with multiple biological roles. In the animal world, it links the
metabolism of carbon and nitrogen and, depending on the need, serves either as a source …

Summary y-Aminobutyric acid (CABA) is the most widely distributed known inhibitory
neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in …

Glutamate decarboxylase (GAD) catalyzes the production of γ‐aminobutyric acid (GABA), a
major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms …

γ‐Aminobutyric acid (GABA) is synthesized in brain in at least two compartments, commonly
called the transmitter and metabolic compartments, and because reglatory processes must …

Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most
common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous …

DOPAMINERGIC neuronal pathways arise from mesencephalic nuclei and project axons to
the striatum, cortex, limbic system and hypothalamus1, 2. Through these pathways …

Abstract INSULIN-DEPENDENT diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice
results from the T-lymphocyte-mediated destruction of the insulin-producing pancreatic β …

We report the isolation and sequencing of cDNAs encoding two human glutamate
decarboxylases (GADs; L-glutamate 1-carboxy-lyase, EC 4.1. 1.15), GAD65 and GAD67 …

Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid
decarboxylase; GAD; EC 4.1. 1.15) began in 1951 with the work of Roberts and his …