Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

S Dallavalle, V Dobričić, L Lazzarato, E Gazzano… - Drug Resistance …, 2020 - Elsevier
Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …

Rational design of cancer nanomedicine for simultaneous stealth surface and enhanced cellular uptake

Q Jin, Y Deng, X Chen, J Ji - Acs Nano, 2019 - ACS Publications
Owing to the complex and still not fully understood physiological environment, the
development of traditional nanosized drug delivery systems is very challenging for precision …

[HTML][HTML] Tumor microenvironment-based stimuli-responsive nanoparticles for controlled release of drugs in cancer therapy

W Zhou, Y Jia, Y Liu, Y Chen, P Zhao - Pharmaceutics, 2022 - mdpi.com
With the development of nanomedicine technology, stimuli-responsive nanocarriers play an
increasingly important role in antitumor therapy. Compared with the normal physiological …

Disulfide‐bridged organosilica frameworks: designed, synthesis, redox‐triggered biodegradation, and nanobiomedical applications

X Du, F Kleitz, X Li, H Huang, X Zhang… - Advanced Functional …, 2018 - Wiley Online Library
Over the past few years, silica‐based nanotheranostics have demonstrated their great
potential for nano/biomedical applications. However, the uncontrollable and difficult …

The development of phosphorescent probes for in vitro and in vivo bioimaging

X Zhen, R Qu, W Chen, W Wu, X Jiang - Biomaterials science, 2021 - pubs.rsc.org
Phosphorescence is a process that slowly releases the photoexcitation energy after the
removal of the excitation source. Although transition metal complexes and purely organic …

Redox and near-infrared light-responsive nanoplatform for enhanced pesticide delivery and pest control in rice: construction, efficacy, and potential mechanisms

M Zong, C Yu, J Li, D Sun, J Wang, Z Mo… - … Applied Materials & …, 2023 - ACS Publications
The brown planthopper, Nilaparvata lugens (Stål), is a major rice pest in various Asian
countries, causing significant negative impacts on rice yield and quality. In this study, we …

[HTML][HTML] Targeting tumor microenvironment by small-molecule inhibitors

S Zhong, JH Jeong, Z Chen, Z Chen, JL Luo - Translational oncology, 2020 - Elsevier
The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell–
enriched milieu that plays crucial roles in tumor development, growth, progression, and …

[HTML][HTML] Mesoporous silica nanoparticles: Properties and strategies for enhancing clinical effect

AN Frickenstein, JM Hagood, CN Britten, BS Abbott… - Pharmaceutics, 2021 - mdpi.com
Due to the theragnostic potential of mesoporous silica nanoparticles (MSNs), these were
extensively investigated as a novel approach to improve clinical outcomes. Boasting an …

[HTML][HTML] The tumour microenvironment as an integrated framework to understand cancer biology

R Burgos-Panadero, F Lucantoni… - Cancer Letters, 2019 - Elsevier
Cancer cells all share the feature of being immersed in a complex environment with altered
cell-cell/cell-extracellular element communication, physicochemical information, and tissue …

A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic-chemo therapy system

Q Li, W Li, H Di, L Luo, C Zhu, J Yang, X Yin… - Journal of Controlled …, 2018 - Elsevier
The targeted drug delivery with the help of nanocarriers and the controlled drug release at
the lesion sites are the most effective ways to enhance therapeutic efficacy and reduce side …