The etiology of preeclampsia

E Jung, R Romero, L Yeo, N Gomez-Lopez… - American journal of …, 2022 - Elsevier
Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlapping pathologic processes activate a common pathway consisting of endothelial cell …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors

T Tomimatsu, K Mimura, S Matsuzaki, M Endo… - International journal of …, 2019 - mdpi.com
Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …

The competing risk approach for prediction of preeclampsia

D Wright, A Wright, KH Nicolaides - American journal of obstetrics and …, 2020 - Elsevier
The established method of the assessment of the risk for development of preeclampsia is to
identify risk factors from maternal demographic characteristics and medical history; in the …

Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity

R Romero, O Erez, M Hüttemann, E Maymon… - American journal of …, 2017 - Elsevier
Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

Early prediction of preeclampsia

LC Poon, KH Nicolaides - Obstetrics and gynecology …, 2014 - Wiley Online Library
Effective screening for the development of early onset preeclampsia (PE) can be provided in
the first‐trimester of pregnancy. Screening by a combination of maternal risk factors, uterine …

[HTML][HTML] Implementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice

H Stepan, I Herraiz, D Schlembach… - … in Obstetrics & …, 2015 - ncbi.nlm.nih.gov
Pre-eclampsia (PE) is a leading cause of maternal and fetal/neonatal morbidity and mortality
worldwide. Clinical diagnosis and definition of PE is commonly based on the measurement …

Meta-analysis and systematic review to assess the role of soluble FMS-like tyrosine kinase-1 and placenta growth factor ratio in prediction of preeclampsia: the …

S Agrawal, AS Cerdeira, C Redman, M Vatish - Hypertension, 2018 - Am Heart Assoc
Preeclampsia is a major cause of morbidity and mortality worldwide. Numerous candidate
biomarkers have been proposed for diagnosis and prediction of preeclampsia …

Plastics derived endocrine‐disrupting compounds and their effects on early development

S Basak, MK Das, AK Duttaroy - Birth defects research, 2020 - Wiley Online Library
Despite the fact that the estrogenic effects of bisphenols were first described 80 years ago,
recent data about its potential negative impact on birth outcome parameters raises a strong …

Circulating angiogenic factor levels in hypertensive disorders of pregnancy

R Thadhani, E Lemoine, S Rana… - NEJM …, 2022 - evidence.nejm.org
Background Among women with hypertensive disorders of pregnancy, biomarkers may
stratify risk for developing preeclampsia with severe features (sPE). Methods Across 18 US …