Organelle-level precision with next-generation targeting technologies
Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles
R Mohammadinejad, MA Moosavi, S Tavakol… - Autophagy, 2019 - Taylor & Francis
Nanomaterials have gained a rapid increase in use in a variety of applications that pertain to
many aspects of human life. The majority of these innovations are centered on medical …
many aspects of human life. The majority of these innovations are centered on medical …
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
M Mauthe, I Orhon, C Rocchi, X Zhou, M Luhr… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …
sequestered by phagophores, which mature into autophagosomes, and then delivered into …
Biodistribution, clearance, and long‐term fate of clinically relevant nanomaterials
Realization of the immense potential of nanomaterials for biomedical applications will
require a thorough understanding of how they interact with cells, tissues, and organs. There …
require a thorough understanding of how they interact with cells, tissues, and organs. There …
Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease
DJ Colacurcio, RA Nixon - Ageing research reviews, 2016 - Elsevier
Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Laser ablation as a versatile tool to mimic polyethylene terephthalate nanoplastic pollutants: characterization and toxicology assessment
The presence of micro-and nanoplastics in the marine environment is raising strong
concerns since they can possibly have a negative impact on human health. In particular, the …
concerns since they can possibly have a negative impact on human health. In particular, the …
[HTML][HTML] Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …
[HTML][HTML] Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …